Replacement of Chalcone-Ethers with Chalcone-Thioethers as Potent and Highly Selective Monoamine Oxidase-B Inhibitors and Their Protein-Ligand Interactions

• Main Authors: Bijo Mathew (Author), Jong Min Oh (Author), Ahmed Khames (Author), Mohamed A. Abdelgawad (Author), T. M. Rangarajan (Author), Lekshmi R. Nath (Author), Clement Agoni (Author), Mahmoud E. S. Soliman (Author), Githa Elizabeth Mathew (Author), Hoon Kim (Author)
• Format: Book
• Published: MDPI AG, 2021-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

To develop new potent and highly selective MAO-B inhibitors from chalcone-thioethers, eleven chalcones-thioethers were synthesized and their monoamine oxidase (MAO) inhibition, kinetics, reversibility, and cytotoxicity of lead compounds were analyzed. Molecular dynamics were carried out to investiga...