The Two Formyl Peptide Receptors Differently Regulate GPR84-Mediated Neutrophil NADPH Oxidase Activity

• Main Authors: Jonas Mårtensson (Author), Martina Sundqvist (Author), Asmita Manandhar (Author), Loukas Ieremias (Author), Linjie Zhang (Author), Trond Ulven (Author), Xin Xie (Author), Lena Björkman (Author), Huamei Forsman (Author)
• Format: Book
• Published: Karger Publishers, 2021-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Neutrophils express the two formyl peptide receptors (FPR1 and FPR2) and the medium-chain fatty acid receptor GPR84. The FPRs are known to define a hierarchy among neutrophil G protein-coupled receptors (GPCRs), that is, the activated FPRs can either suppress or amplify GPCR responses. In this study...