Transcription factor OTX2 silences the expression of cleavage embryo genes and transposable elements
Upon mammalian fertilization, zygotic genome activation (ZGA) and activation of transposable elements (TEs) occur in early embryos to establish totipotency and support embryogenesis. However, the molecular mechanisms controlling the expression of these genes in mammals remain poorly understood. The...
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The Society for Reproduction and Development,
2021-04-01T00:00:00Z.
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