DoE-Based Design of a Simple but Efficient Preparation Method for a Non-Effervescent Gastro-Retentive Floating Tablet Containing Metformin HCl

• Main Authors: Byungsuk Kim (Author), Youngjoo Byun (Author), Eun Hee Lee (Author)
• Format: Knjiga
• Izdano: MDPI AG, 2021-08-01T00:00:00Z.
• Teme: article
• Online dostop: Connect to this object online.

A sustained-release non-effervescent floating matrix tablet was prepared using a simple and efficient direct compression of spray-dried granules containing metformin hydrochloride and cetyl alcohol with hydroxypropyl methylcellulose K15M (HPMC K15M). The design of experiments was employed to explore...