cCPE Fusion Proteins as Molecular Probes to Detect Claudins and Tight Junction Dysregulation in Gastrointestinal Cell Lines, Tissue Explants and Patient-Derived Organoids

• Main Authors: Ayk Waldow (Author), Laura-Sophie Beier (Author), Janine Arndt (Author), Simon Schallenberg (Author), Claudia Vollbrecht (Author), Philip Bischoff (Author), Martí Farrera-Sal (Author), Florian N. Loch (Author), Christian Bojarski (Author), Michael Schumann (Author), Lars Winkler (Author), Carsten Kamphues (Author), Lukas Ehlen (Author), Jörg Piontek (Author)
• Format: Book
• Published: MDPI AG, 2023-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Claudins regulate paracellular permeability, contribute to epithelial polarization and are dysregulated during inflammation and carcinogenesis. Variants of the claudin-binding domain of <i>Clostridium perfringens</i> enterotoxin (cCPE) are highly sensitive protein ligands for generic det...