cCPE Fusion Proteins as Molecular Probes to Detect Claudins and Tight Junction Dysregulation in Gastrointestinal Cell Lines, Tissue Explants and Patient-Derived Organoids

• Prif Awduron: Ayk Waldow (Awdur), Laura-Sophie Beier (Awdur), Janine Arndt (Awdur), Simon Schallenberg (Awdur), Claudia Vollbrecht (Awdur), Philip Bischoff (Awdur), Martí Farrera-Sal (Awdur), Florian N. Loch (Awdur), Christian Bojarski (Awdur), Michael Schumann (Awdur), Lars Winkler (Awdur), Carsten Kamphues (Awdur), Lukas Ehlen (Awdur), Jörg Piontek (Awdur)
• Fformat: Llyfr
• Cyhoeddwyd: MDPI AG, 2023-07-01T00:00:00Z.
• Pynciau: article
• Mynediad Ar-lein: Connect to this object online.

Claudins regulate paracellular permeability, contribute to epithelial polarization and are dysregulated during inflammation and carcinogenesis. Variants of the claudin-binding domain of <i>Clostridium perfringens</i> enterotoxin (cCPE) are highly sensitive protein ligands for generic det...