Potential factors contributing to the poor antimicrobial efficacy of SAAP-148 in a rat wound infection model

• Main Authors: Gabrielle S. Dijksteel (Author), Magda M. W. Ulrich (Author), Marcel Vlig (Author), Peter H. Nibbering (Author), Robert A. Cordfunke (Author), Jan W. Drijfhout (Author), Esther Middelkoop (Author), Bouke K. H. L. Boekema (Author)
• Format: Book
• Published: BMC, 2019-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background We investigated the efficacy of a synthetic antimicrobial peptide SAAP-148, which was shown to be effective against Methicillin-resistant Staphylococcus aureus (MRSA) on tape-stripped mice skin. Unexpectedly, SAAP-148 was not effective against MRSA in our pilot study using rats w...