Physicochemical stability of compounded midazolam capsules over a one-year storage period

• Main Authors: Boivin Pierre-Nicolas (Author), Legendre Pauline (Author), Bonnaure Anne-Claire (Author), Lester Marie-Antoinette (Author)
• פורמט: ספר
• יצא לאור: De Gruyter, 2020-05-01T00:00:00Z.
• נושאים: article
• גישה מקוונת: Connect to this object online.

In patients suffering from chronic liver disease, the hepatic metabolism of drugs is perturbed and the metabolic capacity is difficult to assess. Midazolam could be used as a phenotypical probe to predict the metabolic capacity of CYP3A to adjust dosages of drug substrates of this cytochrome. In thi...