Enhanced Oral Bioavailability, Anti-Tumor Activity and Hepatoprotective Effect of 6-Shogaol Loaded in a Type of Novel Micelles of Polyethylene Glycol and Linoleic Acid Conjugate

• Main Authors: Huiyun Zhang (Author), Qilong Wang (Author), Congyong Sun (Author), Yuan Zhu (Author), Qiuxuan Yang (Author), Qiuyu Wei (Author), Jiaxin Chen (Author), Wenwen Deng (Author), Michael Adu-Frimpong (Author), Jiangnan Yu (Author), Ximing Xu (Author)
• Format: Book
• Published: MDPI AG, 2019-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

：6-shogaol is a promising anti-cancer and anti-inflammatory agent. However, the treatment effectiveness of 6-shogaol is limited by poor water solubility, poor oral absorption and rapid metabolism. Herein, 6-shogaol loaded in micelles (SMs) were designed to improve 6-shogaol’s solubility and bioavail...