Improvement of mRNA Delivery Efficiency to a T Cell Line by Modulating PEG-Lipid Content and Phospholipid Components of Lipid Nanoparticles

• Autori principali: Hiroki Tanaka (Autore), Ryo Miyama (Autore), Yu Sakurai (Autore), Shinya Tamagawa (Autore), Yuta Nakai (Autore), Kota Tange (Autore), Hiroki Yoshioka (Autore), Hidetaka Akita (Autore)
• Natura: Libro
• Pubblicazione: MDPI AG, 2021-12-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

(1) Background: T cells are important target cells, since they exert direct cytotoxic effects on infected/malignant cells, and affect the regulatory functions of other immune cells in a target antigen-specific manner. One of the current approaches for modifying the function of T cells is gene transf...