Improvement of mRNA Delivery Efficiency to a T Cell Line by Modulating PEG-Lipid Content and Phospholipid Components of Lipid Nanoparticles

• Main Authors: Hiroki Tanaka (Author), Ryo Miyama (Author), Yu Sakurai (Author), Shinya Tamagawa (Author), Yuta Nakai (Author), Kota Tange (Author), Hiroki Yoshioka (Author), Hidetaka Akita (Author)
• Format: Book
• Published: MDPI AG, 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

(1) Background: T cells are important target cells, since they exert direct cytotoxic effects on infected/malignant cells, and affect the regulatory functions of other immune cells in a target antigen-specific manner. One of the current approaches for modifying the function of T cells is gene transf...