4-Substituted Thieno[3,2-<i>d</i>]pyrimidines as Dual-Stage Antiplasmodial Derivatives

• Main Authors: Prisca Lagardère (Author), Romain Mustière (Author), Nadia Amanzougaghene (Author), Sébastien Hutter (Author), Jean-François Franetich (Author), Nadine Azas (Author), Patrice Vanelle (Author), Pierre Verhaeghe (Author), Nicolas Primas (Author), Dominique Mazier (Author), Nicolas Masurier (Author), Vincent Lisowski (Author)
• Format: Bog
• Udgivet: MDPI AG, 2022-07-01T00:00:00Z.
• Fag: article
• Online adgang: Connect to this object online.

Malaria remains one of the major health problems worldwide. The increasing resistance of <i>Plasmodium</i> to approved antimalarial drugs requires the development of novel antiplasmodial agents that can effectively prevent and/or treat this disease. Based on the structure of Gamhepathiop...