Intrinsic activation of the vitamin D antimicrobial pathway by M. leprae infection is inhibited by type I IFN.

• Auteurs principaux: Kathryn Zavala (Auteur), Carter A Gottlieb (Auteur), Rosane M Teles (Auteur), John S Adams (Auteur), Martin Hewison (Auteur), Robert L Modlin (Auteur), Philip T Liu (Auteur)
• Format: Livre
• Publié: Public Library of Science (PLoS), 2018-10-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

Following infection, virulent mycobacteria persist and grow within the macrophage, suggesting that the intrinsic activation of an innate antimicrobial response is subverted by the intracellular pathogen. For Mycobacterium leprae, the intracellular bacterium that causes leprosy, the addition of exoge...