Epigenetic regulation of IPF fibroblast phenotype by glutaminolysis

• Hoofdauteurs: Zheyi Xiang (Auteur), Le Bai (Auteur), Jennifer Q. Zhou (Auteur), Ricardo R. Cevallos (Auteur), Jonathan R. Sanders (Auteur), Gang Liu (Auteur), Karen Bernard (Auteur), Yan Y. Sanders (Auteur)
• Formaat: Boek
• Gepubliceerd in: Elsevier, 2023-01-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Objective: Excessive extra-cellular-matrix production and uncontrolled proliferation of the fibroblasts are characteristics of many fibrotic diseases, including idiopathic pulmonary fibrosis (IPF). The fibroblasts have enhanced glutaminolysis with up-regulated glutaminase, GLS1, which converts gluta...