Epigenetic regulation of IPF fibroblast phenotype by glutaminolysis

• Auteurs principaux: Zheyi Xiang (Auteur), Le Bai (Auteur), Jennifer Q. Zhou (Auteur), Ricardo R. Cevallos (Auteur), Jonathan R. Sanders (Auteur), Gang Liu (Auteur), Karen Bernard (Auteur), Yan Y. Sanders (Auteur)
• Format: Livre
• Publié: Elsevier, 2023-01-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

Objective: Excessive extra-cellular-matrix production and uncontrolled proliferation of the fibroblasts are characteristics of many fibrotic diseases, including idiopathic pulmonary fibrosis (IPF). The fibroblasts have enhanced glutaminolysis with up-regulated glutaminase, GLS1, which converts gluta...