Epigenetic regulation of IPF fibroblast phenotype by glutaminolysis

• Main Authors: Zheyi Xiang (Author), Le Bai (Author), Jennifer Q. Zhou (Author), Ricardo R. Cevallos (Author), Jonathan R. Sanders (Author), Gang Liu (Author), Karen Bernard (Author), Yan Y. Sanders (Author)
• Format: Book
• Published: Elsevier, 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Excessive extra-cellular-matrix production and uncontrolled proliferation of the fibroblasts are characteristics of many fibrotic diseases, including idiopathic pulmonary fibrosis (IPF). The fibroblasts have enhanced glutaminolysis with up-regulated glutaminase, GLS1, which converts gluta...