Melatonin Bioavailability After Oral Administration of a New Delayed-Release Form in Healthy Male Volunteers

• Main Authors: Samira Ait Abdellah (Author), Caroline Gal (Author), Isabelle Guinobert (Author), Valérie Bardot (Author), Véronique Raverot (Author), Annarita Vitacca (Author), Claude Blondeau (Author), Bruno Claustrat (Author)
• Format: Book
• Published: Adis, Springer Healthcare, 2024-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Two main types of galenic formulation, immediate release and prolonged release, have been developed to optimize melatonin bioavailability. We recently described the kinetic profile of a prolonged-release form generating a peak of plasma melatonin 1 h (T max) after intake, followe...