IDH2 Deficiency Promotes Endothelial Senescence by Eliciting miR-34b/c-Mediated Suppression of Mitophagy and Increased ROS Production

• Main Authors: Ikjun Lee (Author), Shuyu Piao (Author), Seonhee Kim (Author), Harsha Nagar (Author), Su-jeong Choi (Author), Minsoo Kim (Author), Giang-Huong Vu (Author), Byeong-Hwa Jeon (Author), Cuk-Seong Kim (Author)
• Format: Book
• Published: MDPI AG, 2023-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Endothelial senescence impairs vascular function and thus is a primary event of age-related vasculature diseases. Isocitrate dehydrogenase 2 (IDH2) plays an important role in inducing alpha-ketoglutarate (α-KG) production and preserving mitochondrial function. However, the mechanism and regulation o...