IDH2 Deficiency Promotes Endothelial Senescence by Eliciting miR-34b/c-Mediated Suppression of Mitophagy and Increased ROS Production

• Principais autores: Ikjun Lee (Autor), Shuyu Piao (Autor), Seonhee Kim (Autor), Harsha Nagar (Autor), Su-jeong Choi (Autor), Minsoo Kim (Autor), Giang-Huong Vu (Autor), Byeong-Hwa Jeon (Autor), Cuk-Seong Kim (Autor)
• Formato: Livro
• Publicado em: MDPI AG, 2023-02-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Endothelial senescence impairs vascular function and thus is a primary event of age-related vasculature diseases. Isocitrate dehydrogenase 2 (IDH2) plays an important role in inducing alpha-ketoglutarate (α-KG) production and preserving mitochondrial function. However, the mechanism and regulation o...