Factors Influencing the Intracellular Concentrations of the Sofosbuvir Metabolite GS-331007 (in PBMCs) at 30 Days of Therapy

• Main Authors: Jessica Cusato (Author), Lucio Boglione (Author), Amedeo De Nicolò (Author), Gian Paolo Caviglia (Author), Simone Mornese Pinna (Author), Alessia Ciancio (Author), Giulia Troshina (Author), Antonina Smedile (Author), Miriam Antonucci (Author), Valeria Avataneo (Author), Alice Palermiti (Author), Jacopo Mula (Author), Alessandra Manca (Author), Giuseppe Cariti (Author), Marco Cantù (Author), Giorgio Maria Saracco (Author), Giovanni Di Perri (Author), Antonio D'Avolio (Author)
• Format: Book
• Published: MDPI AG, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Sofosbuvir (SOF) is an HCV NS5B polymerase inhibitor, and GS-331007 is its major metabolite. The aim of this study was to investigate whether clinical and pharmacological factors could influence GS-331007 intracellular (IC) concentrations in peripheral blood mononuclear cells (PBMCs) associated with...