In-silico analysis of TCGA data showing multiple POLE-like favourable subgroups overlapping with TP53 mutated endometrial cancer: Implications for clinical practice in low and middle-income countries

In-silico analysis of TCGA data showing multiple POLE-like favourable subgroups overlapping with TP53 mutated endometrial cancer: Implications for clinical practice in low and middle-income countries

Introduction: The Cancer Genome Atlas cohort of endometrial carcinoma (TCGA-UCEC) includes almost 40% TP53-mutants encompassing missense and truncated variants. TCGA revealed 'POLE', characterized by POLE gene bearing exonuclease domain mutation (EDM), as the prognostically best molecular...

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Main Authors: Damayanti Das Ghosh (Author), Rahul Roy Chowdhury (Author), Rajeswari Dutta (Author), Indranil Mukhopadhyay (Author), Asima Mukhopadhyay (Author), Susanta Roychoudhury (Author)
Format: Book
Published: Elsevier, 2023-06-01T00:00:00Z.
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