Substance P participates in periodontitis by upregulating HIF-1α and RANKL/OPG ratio

• Main Authors: Kaixian Yan (Author), Qin Lin (Author), Kailiang Tang (Author), Shuang Liu (Author), Yi Du (Author), Xijiao Yu (Author), Shu Li (Author)
• Format: Book
• Published: BMC, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Both substance P and hypoxia-inducible factor 1 alpha (HIF-1α) are involved in inflammation and angiogenesis. However, the relationship between substance P and HIF-1α in rat periodontitis is still unknown. Methods Ligation-induced rat periodontitis was established to observe the...