Substance P participates in periodontitis by upregulating HIF-1α and RANKL/OPG ratio

• Главные авторы: Kaixian Yan (Автор), Qin Lin (Автор), Kailiang Tang (Автор), Shuang Liu (Автор), Yi Du (Автор), Xijiao Yu (Автор), Shu Li (Автор)
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• Опубликовано: BMC, 2020-01-01T00:00:00Z.
• Предметы: article
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Abstract Background Both substance P and hypoxia-inducible factor 1 alpha (HIF-1α) are involved in inflammation and angiogenesis. However, the relationship between substance P and HIF-1α in rat periodontitis is still unknown. Methods Ligation-induced rat periodontitis was established to observe the...