A practical strategy to develop isoform-selective near-infrared fluorescent probes for human cytochrome P450 enzymes

• Main Authors: Lei Feng (Author), Xiangge Tian (Author), Dahong Yao (Author), Zhenlong Yu (Author), Xiaokui Huo (Author), Zhenhao Tian (Author), Jing Ning (Author), Jingnan Cui (Author), Tony D. James (Author), Xiaochi Ma (Author)
• Format: Book
• Published: Elsevier, 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Currently, the development of selective fluorescent probes toward targeted enzymes is still a great challenge, due to the existence of numerous isoenzymes that share similar catalytic capacity. Herein, a double-filtering strategy was established to effectively develop isoenzyme-specific fluorescent...