The 19-bp deletion polymorphism of dihydrofolate reductase (DHFR) and nonsyndromic cleft lip with or without cleft palate: evidence for a protective role

• Main Authors: Firoozeh RAFIGHDOOST (Author), Amir RAFIGHDOOST (Author), Houshang RAFIGHDOOST (Author), Mohammad-Ayoo (Author), Mohammad HASHEMI (Author), Ebrahim ESKANDARI-NASAB (Author)
• Format: Book
• Published: University of São Paulo, 2015-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective Nonsyndromic cleft lip with or without cleft palate (NS-CL/P) are among the most common congenital birth defects worldwide. Several lines of evidence point to the involvement of folate, as well as folate metabolizing enzymes in risk reduction of orofacial clefts. Dihydrofolate reductase (D...