Receptor Specificity Engineering of TNF Superfamily Ligands

• Váldodahkkit: Fengzhi Suo (Dahkki), Xinyu Zhou (Dahkki), Rita Setroikromo (Dahkki), Wim J. Quax (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: MDPI AG, 2022-01-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

The tumor necrosis factor (TNF) ligand family has nine ligands that show promiscuity in binding multiple receptors. As different receptors transduce into diverse pathways, the study on the functional role of natural ligands is very complex. In this review, we discuss the TNF ligands engineering for...