Autophagy resolves early retinal inflammation in Igf1-deficient mice

• Main Authors: Ana I. Arroba (Author), Lourdes Rodríguez-de la Rosa (Author), Silvia Murillo-Cuesta (Author), Laura Vaquero-Villanueva (Author), Juan M. Hurlé (Author), Isabel Varela-Nieto (Author), Ángela M. Valverde (Author)
• Format: Book
• Published: The Company of Biologists, 2016-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Insulin-like growth factor-1 (IGF-1) is a growth factor with differentiating, anti-apoptotic and metabolic functions in the periphery, and anti-inflammatory properties in the nervous system. Mice that have mutations in the Igf1 gene, rendering the gene product inactive (Igf1−/−), present with age-re...