Ultra-sensitive molecular detection of gene fusions from RNA using ASPYRE

• Main Authors: Eleanor R Gray (Author), Justyna M Mordaka (Author), Efthimia R Christoforou (Author), Kristine von Bargen (Author), Nicola D Potts (Author), Christina Xyrafaki (Author), Ana-Luisa Silva (Author), Magdalena Stolarek-Januszkiewicz (Author), Katarzyna Anton (Author), Paulina K Powalowska (Author), Simonetta Andreazza (Author), Alessandro Tomassini (Author), Rebecca N Palmer (Author), Aishling Cooke (Author), Robert J Osborne (Author), Barnaby W Balmforth (Author)
• Format: Book
• Published: BMC, 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background RNA is a critical analyte for unambiguous detection of actionable mutations used to guide treatment decisions in oncology. Currently available methods for gene fusion detection include molecular or antibody-based assays, which suffer from either being limited to single-gene targe...