Enhanced Oral Bioavailability of Domperidone with Piperine in Male Wistar Rats: Involvement of CYP3A1 and P-gp Inhibition
Purpose: Domperidone is a commonly used antiemetic drug. The oral bioavailability of domperidone is very low due to its rapid first pass metabolism in the intestine and liver. Piperine, the main alkaloid present in black pepper has been reported to show inhibitory effects on Cytochrome P-450 (CYP-45...
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| Main Authors: | , |
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| Format: | Book |
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Frontiers Media S.A.,
2017-01-01T00:00:00Z.
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| Call Number: |
A1234.567 |
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| Copy 1 | Available |