Lactate does not activate NF-κB in oxidative tumor cells

• Main Authors: Vincent F Van Hée (Author), Jhudit ePérez-Escuredo (Author), Andrea eCacace (Author), Tamara eCopetti (Author), Pierre eSonveaux (Author)
• Format: Book
• Published: Frontiers Media S.A., 2015-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The lactate anion is currently emerging as an oncometabolite. Lactate, produced and exported by glycolytic and glutaminolytic cells in tumors, can be recycled as an oxidative fuel by oxidative tumors cells. Independently of hypoxia, it can also activate transcription factor hypoxia-inducible factor-...