Development and Physicochemical Characterization of Sirolimus Solid Dispersions Prepared by Solvent Evaporation Method

• Egile Nagusiak: Shahram Emami (Egilea), Hadi Valizadeh (Egilea), Ziba Islambulchilar (Egilea), Parvin Zakeri-Milani (Egilea)
• Formatua: Liburua
• Argitaratua: Tabriz University of Medical Sciences, 2014-12-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Purpose: The aim of the present investigation was preparation and characterization of sirolimus solid dispersions by solvent evaporation technique to improve its dissolution properties. Methods: Polyvinylpyrrolidone (PVP), Poloxamer 188 and Cremophore RH40 were used to prepare the solid dispersions...