Mitigation of Ionizing Radiation-Induced Gastrointestinal Damage by Insulin-Like Growth Factor-1 in Mice

• Main Authors: Jaroslav Pejchal (Author), Ales Tichy (Author), Adela Kmochova (Author), Lenka Fikejzlova (Author), Klara Kubelkova (Author), Marcela Milanova (Author), Anna Lierova (Author), Alzbeta Filipova (Author), Lubica Muckova (Author), Jana Cizkova (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Purpose: Insulin-like growth factor-1 (IGF-1) stimulates epithelial regeneration but may also induce life-threatening hypoglycemia. In our study, we first assessed its safety. Subsequently, we examined the effect of IGF-1 administered in different dose regimens on gastrointestinal damage induced by...