Over-expression of a Codon Optimized Yeast Cytosolic Pyruvate Carboxylase (PYC2) in CHO Cells for an Augmented Lactate Metabolism

• Main Authors: Sanjeev K. Gupta (Author), Ankit Sharma (Author), Hiralal Kushwaha (Author), Pratyoosh Shukla (Author)
• Formato: Livro
• Publicado em: Frontiers Media S.A., 2017-07-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Monoclonal antibodies are the most demanding biotherapeutic drugs now a days used for the cure of various critical illnesses. Chinese hamster ovary (CHO) cells are one of the main hosts used for the large scale production of these antibodies. However, the cell line and production processes are the k...