Progressive Increase of Inflammatory CXCR4 and TNF-Alpha in the Dorsal Root Ganglia and Spinal Cord Maintains Peripheral and Central Sensitization to Diabetic Neuropathic Pain in Rats

• Main Authors: Dan Zhu (Author), Tingting Fan (Author), Xinyue Huo (Author), Jian Cui (Author), Chi Wai Cheung (Author), Zhengyuan Xia (Author)
• Format: Bog
• Udgivet: Hindawi Limited, 2019-01-01T00:00:00Z.
• Fag: article
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Diabetic neuropathic pain (DNP) is a common and serious complication of diabetic patients. The pathogenesis of DNP is largely unclear. The proinflammation proteins, CXCR4, and TNF-α play critical roles in the development of pain, while their relative roles in the development of DNP and especially it...