DNA Aptamers Targeting BACE1 Reduce Amyloid Levels and Rescue Neuronal Deficiency in Cultured Cells

• Main Authors: Jun Xiang (Author), Wen Zhang (Author), Xiao-Fang Cai (Author), Min Cai (Author), Zhong-Hai Yu (Author), Feng Yang (Author), Wen Zhu (Author), Xiang-Ting Li (Author), Ting Wu (Author), Jing-Si Zhang (Author), Ding-Fang Cai (Author)
• Format: Book
• Published: Elsevier, 2019-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

β-amyloid (Aβ) plays an essential role in the pathogenesis of Alzheimer's disease (AD). Beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) is indispensable for Aβ production, and knockout of BACE1 has no overt phenotypes in mouse. Thus, fine modulation of BACE1 may be a safe and effe...