Comprehensive Study of Antiretroviral Drug Permeability at the Cervicovaginal Mucosa <i>via</i> an In Vitro Model

• Egile Nagusiak: Constandinos Carserides (Egilea), Kieron Smith (Egilea), Marta Zinicola (Egilea), Abhinav Kumar (Egilea), Magda Swedrowska (Egilea), Carlo Scala (Egilea), Gary Cameron (Egilea), Zoe Riches (Egilea), Francesco Iannelli (Egilea), Gianni Pozzi (Egilea), Georgina L. Hold (Egilea), Ben Forbes (Egilea), Charles Kelly (Egilea), Karolin Hijazi (Egilea)
• Formatua: Liburua
• Argitaratua: MDPI AG, 2022-09-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Modulation of drug transporter activity at mucosal sites of HIV-1 transmission may be exploited to optimize retention of therapeutic antiretroviral drug concentrations at target submucosal CD4+ T cells. Previously, we showed that darunavir was a substrate for the P-glycoprotein efflux drug transport...