Adjuvant effect of enterotoxigenic Escherichia coli (ETEC) double-mutant heat-labile toxin (dmLT) on systemic immunogenicity induced by the CFA/I/II/IV MEFA ETEC vaccine: Dose-related enhancement of antibody responses to seven ETEC adhesins (CFA/I, CS1-CS6)

• Main Authors: Hyesuk Seo (Author), Ti Lu (Author), Sachin Mani (Author), A. Louis Bourgeois (Author), Richard Walker (Author), David A. Sack (Author), Weiping Zhang (Author)
• Format: Book
• Published: Taylor & Francis Group, 2020-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Double-mutant heat-labile toxin (dmLT, LTR192G/L211A) of enterotoxigenic Escherichia coli (ETEC) is an effective mucosal adjuvant. Recent studies have shown that dmLT also exhibits adjuvanticity for antigens administered parenterally. In this study, we subcutaneously (SC) immunized mice with the ETE...