Continuous direct compression: Development of an empirical predictive model and challenges regarding PAT implementation

• Main Authors: B. Bekaert (Author), B. Van Snick (Author), K. Pandelaere (Author), J. Dhondt (Author), G. Di Pretoro (Author), T. De Beer (Author), C. Vervaet (Author), V. Vanhoorne (Author)
• Format: Book
• Published: Elsevier, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In this study, an empirical predictive model was developed based on the quantitative relationships between blend properties, critical quality attributes (CQA) and critical process parameters (CPP) related to blending and tableting. The blend uniformity and API concentration in the tablets were used...