Mechanistic role of a disease-associated genetic variant within the ADAM33 asthma susceptibility gene

• Main Authors: Keith Tim P (Author), Giese Heidi (Author), Turenne Laura (Author), Del Mastro Richard G (Author), Van Eerdewegh Paul (Author), May Klaus JW (Author), Little Randall D (Author)
• Format: Book
• Published: BMC, 2007-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<p>Abstract</p> <p>Background</p> <p>ADAM33 has been identified as an asthma-associated gene in an out-bred population. Genetic studies suggested that the functional role of this metalloprotease was in airway remodeling. However, the mechanistic roles of the disease-ass...