A potent adjuvant effect of a CD1d-binding NKT cell ligand in human immune system mice

• Main Authors: Xiangming Li (Author), Jing Huang (Author), Izumi Kaneko (Author), Min Zhang (Author), Shiroh Iwanaga (Author), Masao Yuda (Author), Moriya Tsuji (Author)
• Format: Book
• Published: Taylor & Francis Group, 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objectives: A CD1d-binding invariant natural killer T (iNKT)-cell stimulatory glycolipid, namely 7DW8-5, is shown to enhance the efficacy of radiation-attenuated sporozoites (RAS)-based malaria vaccine in mice. In the current study, we aim to determine whether 7DW8-5 can display a potent adjuvant ef...