Neopterin is a cerebrospinal fluid marker for treatment outcome evaluation in patients affected by Trypanosoma brucei gambiense sleeping sickness.

• Main Authors: Natalia Tiberti (Author), Veerle Lejon (Author), Alexandre Hainard (Author), Bertrand Courtioux (Author), Xavier Robin (Author), Natacha Turck (Author), Krister Kristensson (Author), Enock Matovu (Author), John Charles Enyaru (Author), Dieudonné Mumba Ngoyi (Author), Sanjeev Krishna (Author), Sylvie Bisser (Author), Joseph Mathu Ndung'u (Author), Philippe Büscher (Author), Jean-Charles Sanchez (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND: Post-therapeutic follow-up is essential to confirm cure and to detect early treatment failures in patients affected by sleeping sickness (HAT). Current methods, based on finding of parasites in blood and cerebrospinal fluid (CSF) and counting of white blood cells (WBC) in CSF, are imperf...