Determination of the Pharmacokinetics and Pharmacodynamics of Isoniazid, Rifampicin, Pyrazinamide and Ethambutol in a Cross-Over Cynomolgus Macaque Model of <i>Mycobacterium tuberculosis</i> Infection

• Main Authors: Laura Sibley (Author), Andrew D. White (Author), Charlotte Sarfas (Author), Jennie Gullick (Author), Fergus Gleeson (Author), Faye Lanni (Author), Simon Clark (Author), Emma Rayner (Author), Santiago Ferrer-Bazaga (Author), Fatima Ortega-Muro (Author), Laura Alameda (Author), Joaquin Rullas (Author), Veronica Sousa (Author), Marisa Martinez (Author), Inigo Angulo-Barturen (Author), Adolfo Garcia (Author), Juan José Vaquero (Author), Henry E. Pertinez (Author), Geraint Davies (Author), Mike Dennis (Author), Ann Williams (Author), Sally Sharpe (Author)
• Format: Book
• Published: MDPI AG, 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Innovative cross-over study designs were explored in non-human primate (NHP) studies to determine the value of this approach for the evaluation of drug efficacy against tuberculosis (TB). Firstly, the pharmacokinetics (PK) of each of the drugs Isoniazid (H), Rifampicin (R), Pyrazinamide (Z) and Etha...