Autotaxin signaling facilitates β cell dedifferentiation and dysfunction induced by Sirtuin 3 deficiency

• Main Authors: Huanyi Cao (Author), Arthur C.K. Chung (Author), Xing Ming (Author), Dandan Mao (Author), Heung Man Lee (Author), Xiaoyun Cao (Author), Guy A. Rutter (Author), Juliana C.N. Chan (Author), Xiao Yu Tian (Author), Alice P.S. Kong (Author)
• Format: Book
• Published: Elsevier, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: β cell dedifferentiation may underlie the reversible reduction in pancreatic β cell mass and function in type 2 diabetes (T2D). We previously reported that β cell-specific Sirt3 knockout (Sirt3f/f;Cre/+) mice developed impaired glucose tolerance and glucose-stimulated insulin secretion af...