Small molecules targeting Pin1 as potent anticancer drugs

• Main Authors: Jing Zhang (Author), Wenwen Zhou (Author), Yunyu Chen (Author), Yanchang Wang (Author), Zongru Guo (Author), Wenhui Hu (Author), Yan Li (Author), Xiaomin Han (Author), Shuyi Si (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Pin1 is a member of the evolutionarily conserved peptidyl-prolyl isomerase (PPIase) family of proteins. Following phosphorylation, Pin1-catalyzed prolyl-isomerization induces conformational changes, which serve to regulate the function of many phosphorylated proteins that play important...