PDE4B Is a Homeostatic Regulator of Cyclic AMP in Dendritic Cells

• Главные авторы: Amy M. Chinn (Автор), Cristina Salmerón (Автор), Jihyung Lee (Автор), Krishna Sriram (Автор), Eyal Raz (Автор), Paul A. Insel (Автор)
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• Опубликовано: Frontiers Media S.A., 2022-03-01T00:00:00Z.
• Предметы: article
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Chronic decreases in the second messenger cyclic AMP (cAMP) occur in numerous settings, but how cells compensate for such decreases is unknown. We have used a unique system-murine dendritic cells (DCs) with a DC-selective depletion of the heterotrimeric GTP binding protein Gαs-to address this issue....