PDE4B Is a Homeostatic Regulator of Cyclic AMP in Dendritic Cells

• Main Authors: Amy M. Chinn (Author), Cristina Salmerón (Author), Jihyung Lee (Author), Krishna Sriram (Author), Eyal Raz (Author), Paul A. Insel (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Chronic decreases in the second messenger cyclic AMP (cAMP) occur in numerous settings, but how cells compensate for such decreases is unknown. We have used a unique system-murine dendritic cells (DCs) with a DC-selective depletion of the heterotrimeric GTP binding protein Gαs-to address this issue....