In vivo tissue pharmacokinetics of ERBB2‐specific binding oligonucleotide‐based drugs by PET imaging

• Main Authors: Sun Mi Park (Author), Suji Baek (Author), Jung Hwan Lee (Author), Sang‐Keun Woo (Author), Tae Sup Lee (Author), Hyun Soo Park (Author), Jongook Lee (Author), Yeon‐Koo Kang (Author), Seo Young Kang (Author), Min Young Yoo (Author), Hai‐Jeon Yoon (Author), Bom Sahn Kim (Author), Kang Pa Lee (Author), Byung Seok Moon (Author)
• Format: Book
• Published: Wiley, 2023-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Although aptamers have shown excellent target specificity in preclinical and clinical studies either by themselves or as aptamer‐drug conjugates, their in vivo tissue pharmacokinetic (PK) analysis is still problematic. We aimed to examine the utility of image‐based positron emission tomogra...