A Novel Compound, Tanshinol Borneol Ester, Ameliorates Pressure Overload-Induced Cardiac Hypertrophy by Inhibiting Oxidative Stress via the mTOR/β-TrCP/NRF2 Pathway

• Main Authors: Dongjian Han (Author), Fuhang Wang (Author), Bo Wang (Author), Zhentao Qiao (Author), Xinyue Cui (Author), Yi Zhang (Author), Qingjiao Jiang (Author), Miaomiao Liu (Author), Jiahong Shangguan (Author), Xiaohui Zheng (Author), Yajun Bai (Author), Chunyan Du (Author), Deliang Shen (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Tanshinol borneol ester (DBZ) exerts anti-atherosclerotic and anti-inflammatory effects. However, its effects on cardiac hypertrophy are not well understood. In this work, we investigated the treatment effects and potential mechanisms of DBZ on the hypertrophic heart under oxidative stress and endop...