A Novel Compound, Tanshinol Borneol Ester, Ameliorates Pressure Overload-Induced Cardiac Hypertrophy by Inhibiting Oxidative Stress via the mTOR/β-TrCP/NRF2 Pathway

• Главные авторы: Dongjian Han (Автор), Fuhang Wang (Автор), Bo Wang (Автор), Zhentao Qiao (Автор), Xinyue Cui (Автор), Yi Zhang (Автор), Qingjiao Jiang (Автор), Miaomiao Liu (Автор), Jiahong Shangguan (Автор), Xiaohui Zheng (Автор), Yajun Bai (Автор), Chunyan Du (Автор), Deliang Shen (Автор)
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• Опубликовано: Frontiers Media S.A., 2022-02-01T00:00:00Z.
• Предметы: article
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Tanshinol borneol ester (DBZ) exerts anti-atherosclerotic and anti-inflammatory effects. However, its effects on cardiac hypertrophy are not well understood. In this work, we investigated the treatment effects and potential mechanisms of DBZ on the hypertrophic heart under oxidative stress and endop...