Dihydroartemisinin remodels macrophage into an M1 phenotype via ferroptosis-mediated DNA damage

• Main Authors: Liu-Gen Li (Author), Xing-Chun Peng (Author), Ting-Ting Yu (Author), Hua-Zhen Xu (Author), Ning Han (Author), Xiao-Xin Yang (Author), Qi-Rui Li (Author), Jun Hu (Author), Bin Liu (Author), Zi-Yi Yang (Author), Xiang Xu (Author), Xiao Chen (Author), Mei-Fang Wang (Author), Tong-Fei Li (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Lung cancer recruits tumor-associated macrophages (TAMs) massively, whose predominantly pro-tumor M2 phenotype leads to immunosuppression. Dihydroartemisinin (DHA) has been proven to remodel TAM into an anti-tumor M1 phenotype at certain concentrations in the present study, which was hypothesized to...