Dihydroartemisinin remodels macrophage into an M1 phenotype via ferroptosis-mediated DNA damage

• Principais autores: Liu-Gen Li (Autor), Xing-Chun Peng (Autor), Ting-Ting Yu (Autor), Hua-Zhen Xu (Autor), Ning Han (Autor), Xiao-Xin Yang (Autor), Qi-Rui Li (Autor), Jun Hu (Autor), Bin Liu (Autor), Zi-Yi Yang (Autor), Xiang Xu (Autor), Xiao Chen (Autor), Mei-Fang Wang (Autor), Tong-Fei Li (Autor)
• Formato: Livro
• Publicado em: Frontiers Media S.A., 2022-08-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Lung cancer recruits tumor-associated macrophages (TAMs) massively, whose predominantly pro-tumor M2 phenotype leads to immunosuppression. Dihydroartemisinin (DHA) has been proven to remodel TAM into an anti-tumor M1 phenotype at certain concentrations in the present study, which was hypothesized to...