Non-nucleoside inhibitors of DNMT1 and DNMT3 for targeted cancer therapy

• मुख्य लेखकों: Ting Chen (लेखक), Syrine Mahdadi (लेखक), Michel Vidal (लेखक), Stéphanie Desbène-Finck (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Elsevier, 2024-09-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

DNA methylation can deactivate tumor suppressor genes thus causing cancers. Two DNA methylation inhibitors have been approved by the Food and Drug Administration (FDA) and have entered clinical use. However, these inhibitors are nucleoside analogues that can be incorporated into DNA or RNA and induc...