Roles of SIRT1 and Phosphoinositide 3-OH Kinase/Protein Kinase C Pathways in Evodiamine-Induced Human Melanoma A375-S2 Cell Death

• Auteurs principaux: Che Wang (Auteur), Min-wei Wang (Auteur), Shin-ichi Tashiro (Auteur), Satoshi Onodera (Auteur), Takashi Ikejima (Auteur)
• Format: Livre
• Publié: Elsevier, 2005-01-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

We previously demonstrated that evodimine isolated from Evodia rutaecarpa (Goshuyu in Japan) induced apoptosis in human malignant melanoma A375-S2 cells within 24 h. In this study, TUNEL assay also indicated that one cause of A375-S2 cell death induced by evodiamine was apoptosis. After treatment wi...