Systemic administration of choline acetyltransferase decreases blood pressure in murine hypertension

• Main Authors: Andrew Stiegler (Author), Jian-Hua Li (Author), Vivek Shah (Author), Tea Tsaava (Author), Aisling Tynan (Author), Huan Yang (Author), Yehuda Tamari (Author), Michael Brines (Author), Kevin J. Tracey (Author), Sangeeta S. Chavan (Author)
• Format: Book
• Published: BMC, 2021-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Acetylcholine (ACh) decreases blood pressure by stimulating endothelium nitric oxide-dependent vasodilation in resistance arterioles. Normal plasma contains choline acetyltransferase (ChAT) and its biosynthetic product ACh at appreciable concentrations to potentially act upon the endotheliu...