FGF21 acts in the brain to drive macronutrient-specific changes in behavioral motivation and brain reward signaling

• Main Authors: Md Shahjalal H. Khan (Author), Sora Q. Kim (Author), Robert C. Ross (Author), Florina Corpodean (Author), Redin A. Spann (Author), Diana A. Albarado (Author), Sun O. Fernandez-Kim (Author), Blaise Clarke (Author), Hans-Rudolf Berthoud (Author), Heike Münzberg (Author), David H. McDougal (Author), Yanlin He (Author), Sangho Yu (Author), Vance L. Albaugh (Author), Paul L. Soto (Author), Christopher D. Morrison (Author)
• Format: Book
• Published: Elsevier, 2025-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Dietary protein restriction induces adaptive changes in food preference, increasing protein consumption over carbohydrates or fat. We investigated whether motivation and reward signaling underpin these preferences. Methods and Results: In an operant task, protein-restricted male mice resp...