The novel small-molecule antagonist of PAC1 receptor attenuates formalin-induced inflammatory pain behaviors in mice

• Main Authors: Ichiro Takasaki (Author), Koji Nakamura (Author), Ayaka Shimodaira (Author), Ai Watanabe (Author), Huy Du Nguyen (Author), Takuya Okada (Author), Naoki Toyooka (Author), Atsuro Miyata (Author), Takashi Kurihara (Author)
• Format: Book
• Published: Elsevier, 2019-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We recently developed PA-8, a novel small-molecule antagonist of PACAP type 1 (PAC1) receptor. In the present study, we examined whether PA-8 was effective against formalin-induced inflammatory pain in mice. Both intrathecal and oral administration of PA-8 resulted in the dose-dependent attenuation...