Genetic Variation in <i>CYP2D6</i> and <i>SLC22A1</i> Affects Amlodipine Pharmacokinetics and Safety

• Main Authors: Paula Soria-Chacartegui (Author), Pablo Zubiaur (Author), Dolores Ochoa (Author), Gonzalo Villapalos-García (Author), Manuel Román (Author), Miriam Matas (Author), Laura Figueiredo-Tor (Author), Gina Mejía-Abril (Author), Sofía Calleja (Author), Alejandro de Miguel (Author), Marcos Navares-Gómez (Author), Samuel Martín-Vilchez (Author), Francisco Abad-Santos (Author)
• Format: Book
• Published: MDPI AG, 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Amlodipine is an antihypertensive drug with unknown pharmacogenetic biomarkers. This research is a candidate gene study that looked for associations between amlodipine pharmacokinetics and safety and pharmacogenes. Pharmacokinetic and safety data were taken from 160 volunteers from eight bioequivale...