Human PARP1 substrates and regulators of its catalytic activity: An updated overview

• Main Authors: Tao Zhu (Author), Ju-Yan Zheng (Author), Ling-Ling Huang (Author), Yan-Hong Wang (Author), Di-Fei Yao (Author), Hai-Bin Dai (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Poly (ADP-ribose) polymerase 1 (PARP1) is a key DNA damage sensor that is recruited to damaged sites after DNA strand breaks to initiate DNA repair. This is achieved by catalyzing attachment of ADP-ribose moieties, which are donated from NAD+, on the amino acid residues of itself or other acceptor p...