Improved intestinal absorption of paclitaxel by mixed micelles self-assembled from vitamin E succinate-based amphiphilic polymers and their transcellular transport mechanism and intracellular trafficking routes

• Main Authors: Xiaoyou Qu (Author), Yang Zou (Author), Chuyu He (Author), Yuanhang Zhou (Author), Yao Jin (Author), Yunqiang Deng (Author), Ziqi Wang (Author), Xinru Li (Author), Yanxia Zhou (Author), Yan Liu (Author)
• Format: Book
• Published: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

To ensure that antitumor drugs can be effectively transported across intestinal barrier and then quickly released in tumor cells, mixed polymeric micelles (Mix-PMs) were designed and fabricated by combining poly(2-ethyl-2-oxazoline)-vitamin E succinate (PEOz-VES) with TPGS1000 for enhancing intestin...